Drug interactions
Crofelemer + Montelukast
Severity: Minor
Crofelemer and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed and may inhibit CYP3A4 only within the gut. Montelukast is mainly cleared by CYP2C8 with contributions from CYP3A4 and CYP2C9, so no meaningful change in exposure is expected.
What this interaction means in plain words
Crofelemer and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Montelukast belongs to Respiratory.
Why it happens
Possible local intestinal CYP3A4 inhibition by crofelemer with negligible systemic effect.
What to do
No action is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Montelukast?
MediHelp rates the interaction as minor. Crofelemer and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed and may inhibit CYP3A4 only within the gut. Montelukast is mainly cleared by CYP2C8 with contributions from CYP3A4 and CYP2C9, so no meaningful change in exposure is expected.
How serious is the interaction between Crofelemer and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is required.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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