Drug interactions
Crofelemer + Progesterone
Severity: Minor
Crofelemer and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed and might inhibit CYP3A4 only in the gut lumen. A clinically important change in progesterone exposure is unlikely.
What this interaction means in plain words
Crofelemer and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Progesterone belongs to Endocrine.
Why it happens
Potential local intestinal CYP3A4 inhibition by crofelemer; negligible systemic effect.
What to do
No action is generally required; monitor for increased progestogenic effects only if oral progesterone is used at high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Progesterone?
MediHelp rates the interaction as minor. Crofelemer and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed and might inhibit CYP3A4 only in the gut lumen. A clinically important change in progesterone exposure is unlikely.
How serious is the interaction between Crofelemer and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally required; monitor for increased progestogenic effects only if oral progesterone is used at high doses.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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