Drug interactions
Crofelemer + Vilazodone
Severity: Minor
Crofelemer and Vilazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer may inhibit CYP3A4 in the gut lumen, but it is minimally absorbed so systemic inhibition is unlikely. A clinically meaningful rise in vilazodone levels is therefore improbable.
What this interaction means in plain words
Crofelemer and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Vilazodone belongs to Central Nervous System.
Why it happens
Possible intestinal CYP3A4 inhibition by crofelemer, with negligible systemic exposure.
What to do
No dose change is generally needed. Monitor for vilazodone adverse effects such as nausea, diarrhea or serotonergic symptoms if a change occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Vilazodone?
MediHelp rates the interaction as minor. Crofelemer and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer may inhibit CYP3A4 in the gut lumen, but it is minimally absorbed so systemic inhibition is unlikely. A clinically meaningful rise in vilazodone levels is therefore improbable.
How serious is the interaction between Crofelemer and Vilazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor for vilazodone adverse effects such as nausea, diarrhea or serotonergic symptoms if a change occurs.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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