Drug interactions
Danicopan + Ivermectin
Severity: Minor
Danicopan and Ivermectin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and may increase systemic ivermectin exposure. Adverse effects are unlikely at standard doses but possible with higher exposure.
What this interaction means in plain words
Danicopan and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Danicopan belongs to Miscellaneous; Ivermectin belongs to Anti Parasitic.
Why it happens
Danicopan inhibits intestinal and other P-glycoprotein transport of ivermectin.
What to do
No empirical dose change is generally needed for single-dose therapy. Monitor for ivermectin adverse effects if repeated dosing is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Ivermectin?
MediHelp rates the interaction as minor. Danicopan and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danicopan inhibits P-glycoprotein and may increase systemic ivermectin exposure. Adverse effects are unlikely at standard doses but possible with higher exposure.
How serious is the interaction between Danicopan and Ivermectin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is generally needed for single-dose therapy. Monitor for ivermectin adverse effects if repeated dosing is required.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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