Drug interactions
Danicopan + Posaconazole
Severity: Minor
Danicopan and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and may increase posaconazole exposure. The clinical impact is uncertain but could include more posaconazole-related adverse effects such as gastrointestinal upset, liver enzyme elevation or QT prolongation.
What this interaction means in plain words
Danicopan and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Danicopan belongs to Miscellaneous; Posaconazole belongs to Anti Fungals.
Why it happens
Danicopan inhibits P-gp efflux, potentially increasing posaconazole absorption.
What to do
Monitor for posaconazole adverse effects and consider checking posaconazole trough concentrations and liver tests.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Posaconazole?
MediHelp rates the interaction as minor. Danicopan and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danicopan inhibits P-glycoprotein and may increase posaconazole exposure. The clinical impact is uncertain but could include more posaconazole-related adverse effects such as gastrointestinal upset, liver enzyme elevation or QT prolongation.
How serious is the interaction between Danicopan and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for posaconazole adverse effects and consider checking posaconazole trough concentrations and liver tests.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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