Drug interactions
Dantrolene + Metoclopramide
Severity: Moderate
Dantrolene and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene causes drowsiness, dizziness and weakness, and metoclopramide can add to sedation. The combination may impair alertness and coordination.
What this interaction means in plain words
Dantrolene and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depressant effects.
What to do
Counsel on sedation and driving risk, and monitor for excessive drowsiness. Reduce doses if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Metoclopramide?
MediHelp rates the interaction as moderate. Dantrolene and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene causes drowsiness, dizziness and weakness, and metoclopramide can add to sedation. The combination may impair alertness and coordination.
How serious is the interaction between Dantrolene and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and driving risk, and monitor for excessive drowsiness. Reduce doses if needed.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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