Drug interactions
Dantrolene + Prochlorperazine
Severity: Moderate
Dantrolene and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause drowsiness, dizziness and weakness. Taken together, sedation and impaired coordination may be increased.
What this interaction means in plain words
Dantrolene and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for oversedation and advise patients to avoid driving and alcohol. Reduce doses if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Prochlorperazine?
MediHelp rates the interaction as moderate. Dantrolene and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause drowsiness, dizziness and weakness. Taken together, sedation and impaired coordination may be increased.
How serious is the interaction between Dantrolene and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and advise patients to avoid driving and alcohol. Reduce doses if excessive drowsiness occurs.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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