Drug interactions
Dantrolene + Propofol
Severity: Moderate
Dantrolene and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol is a potent sedative-hypnotic, and dantrolene can add to central depression and muscle weakness. This may deepen sedation or prolong recovery, which is relevant in anesthesia settings.
What this interaction means in plain words
Dantrolene and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Propofol belongs to Central Nervous System.
Why it happens
Additive central nervous system depression and skeletal muscle weakening.
What to do
Titrate propofol to effect and monitor sedation depth, ventilation and oxygenation continuously. Be prepared to support airway and breathing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Propofol
Frequently asked questions
Can I take Dantrolene with Propofol?
MediHelp rates the interaction as moderate. Dantrolene and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol is a potent sedative-hypnotic, and dantrolene can add to central depression and muscle weakness. This may deepen sedation or prolong recovery, which is relevant in anesthesia settings.
How serious is the interaction between Dantrolene and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect and monitor sedation depth, ventilation and oxygenation continuously. Be prepared to support airway and breathing.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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