Drug interactions
Dantrolene + Tucatinib
Severity: Moderate
Dantrolene and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a CYP3A inhibitor that can raise concentrations of CYP3A substrates. Dantrolene is partly metabolized by hepatic enzymes, so exposure may increase, with greater risk of sedation, weakness and hepatotoxicity.
What this interaction means in plain words
Dantrolene and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A, potentially reducing dantrolene metabolism.
What to do
Monitor liver function and for excessive sedation or weakness, and reduce the dantrolene dose if adverse effects occur. Consider alternatives if long-term use is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dantrolene and Tucatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dantrolene
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Dantrolene with Tucatinib?
MediHelp rates the interaction as moderate. Dantrolene and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a CYP3A inhibitor that can raise concentrations of CYP3A substrates. Dantrolene is partly metabolized by hepatic enzymes, so exposure may increase, with greater risk of sedation, weakness and hepatotoxicity.
How serious is the interaction between Dantrolene and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function and for excessive sedation or weakness, and reduce the dantrolene dose if adverse effects occur. Consider alternatives if long-term use is needed.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
