Drug interactions
Defibrotide + Ticlopidine
Severity: Major
Defibrotide and Ticlopidine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has profibrinolytic and antithrombotic activity and may enhance the effects of platelet inhibitors, raising the risk of hemorrhage. Defibrotide labeling advises against concurrent use with systemic anticoagulants or fibrinolytics.
What this interaction means in plain words
Defibrotide and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Defibrotide belongs to Cardiovascular; Ticlopidine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects on hemostasis via platelet inhibition and enhanced fibrinolysis.
What to do
Monitor closely for bleeding and consider holding ticlopidine during defibrotide therapy if the patient is at high bleeding risk.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Defibrotide and Ticlopidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Ticlopidine
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Argatroban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
Frequently asked questions
Can I take Defibrotide with Ticlopidine?
MediHelp rates the interaction as major. Defibrotide and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Defibrotide has profibrinolytic and antithrombotic activity and may enhance the effects of platelet inhibitors, raising the risk of hemorrhage. Defibrotide labeling advises against concurrent use with systemic anticoagulants or fibrinolytics.
How serious is the interaction between Defibrotide and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for bleeding and consider holding ticlopidine during defibrotide therapy if the patient is at high bleeding risk.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
