Drug interactions
Denosumab + Mitomycin
Severity: Moderate
Denosumab and Mitomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitomycin causes cumulative myelosuppression and denosumab has been linked with serious infections. Concurrent use may add to infection risk.
What this interaction means in plain words
Denosumab and Mitomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Mitomycin belongs to Oncology.
Why it happens
Additive pharmacodynamic effect: cytotoxic bone marrow suppression plus RANKL inhibition affecting immune function.
What to do
Monitor blood counts and watch for infection signs. Treat suspected infection promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Frequently asked questions
Can I take Denosumab with Mitomycin?
MediHelp rates the interaction as moderate. Denosumab and Mitomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitomycin causes cumulative myelosuppression and denosumab has been linked with serious infections. Concurrent use may add to infection risk.
How serious is the interaction between Denosumab and Mitomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for infection signs. Treat suspected infection promptly.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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