Drug interactions
DHEA + Ranolazine
Severity: Minor
DHEA and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A clinically meaningful CYP3A4 effect of DHEA on ranolazine is not documented. Any increase in ranolazine exposure could add to QT prolongation, but this is theoretical.
What this interaction means in plain words
DHEA and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
DHEA belongs to Gastrointestinal Tract; Ranolazine belongs to Cardiovascular.
Why it happens
Hypothesised CYP3A4 modulation by DHEA; no established mechanism.
What to do
No dose change is needed. Monitor for dizziness, nausea or QT-related symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of DHEA
- DHEA + Dihydroergotamine Moderate
- DHEA + Dihydroergotamine intranasal Moderate
- DHEA + Ergotamine Moderate
- DHEA + Pimozide Moderate
- DHEA + Dronedarone Minor
- DHEA + Erythromycin base Minor
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take DHEA with Ranolazine?
MediHelp rates the interaction as minor. DHEA and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. A clinically meaningful CYP3A4 effect of DHEA on ranolazine is not documented. Any increase in ranolazine exposure could add to QT prolongation, but this is theoretical.
How serious is the interaction between DHEA and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for dizziness, nausea or QT-related symptoms.
What other medicines interact with DHEA?
MediHelp also lists interactions of DHEA with, for example, Dihydroergotamine, Dihydroergotamine intranasal, Ergotamine. The full list is on the DHEA page.
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