Drug interactions
Digoxin + Ergocalciferol
Severity: Moderate
Digoxin and Ergocalciferol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vitamin D-induced hypercalcemia sensitizes the heart to digoxin and may provoke arrhythmias. This is most relevant with high vitamin D doses.
What this interaction means in plain words
Digoxin and Ergocalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Ergocalciferol belongs to Musculoskeletal.
Why it happens
Hypercalcemia augments the effects of digoxin on myocardial excitability, increasing the risk of toxicity.
What to do
Monitor serum calcium and ECG, and check digoxin levels if symptoms of toxicity occur. Avoid high-dose vitamin D in patients on digoxin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergocalciferol
- Aluminum hydroxide + Ergocalciferol Moderate
- Calcium acetate + Ergocalciferol Moderate
- Calcium carbonate + Ergocalciferol Moderate
- Calcium chloride + Ergocalciferol Moderate
- Calcium citrate + Ergocalciferol Moderate
- Calcium gluconate + Ergocalciferol Moderate
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Ergocalciferol?
MediHelp rates the interaction as moderate. Digoxin and Ergocalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vitamin D-induced hypercalcemia sensitizes the heart to digoxin and may provoke arrhythmias. This is most relevant with high vitamin D doses.
How serious is the interaction between Digoxin and Ergocalciferol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and ECG, and check digoxin levels if symptoms of toxicity occur. Avoid high-dose vitamin D in patients on digoxin.
What other medicines interact with Ergocalciferol?
MediHelp also lists interactions of Ergocalciferol with, for example, Aluminum hydroxide, Calcium acetate, Calcium carbonate. The full list is on the Ergocalciferol page.
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