Drug interactions
Digoxin + Liothyronine
Severity: Moderate
Digoxin and Liothyronine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone replacement increases metabolic rate and digoxin clearance and volume of distribution changes, which can lower digoxin levels and reduce effect in patients who were previously hypothyroid. Correcting hypothyroidism may thus require digoxin dose adjustment.
What this interaction means in plain words
Digoxin and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Liothyronine belongs to Endocrine.
Why it happens
Restoration of euthyroid state increases digoxin clearance and distribution, lowering serum concentrations; exact mechanism is not fully defined.
What to do
Monitor digoxin concentrations and heart rate/clinical response when liothyronine is started or its dose changed, and raise the digoxin dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Digoxin and Liothyronine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Digoxin with Liothyronine?
MediHelp rates the interaction as moderate. Digoxin and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone replacement increases metabolic rate and digoxin clearance and volume of distribution changes, which can lower digoxin levels and reduce effect in patients who were previously hypothyroid. Correcting hypothyroidism may thus require digoxin dose adjustment.
How serious is the interaction between Digoxin and Liothyronine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentrations and heart rate/clinical response when liothyronine is started or its dose changed, and raise the digoxin dose if needed.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
