Drug interactions
Digoxin + Metoclopramide
Severity: Moderate
Digoxin and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide speeds gastric emptying and intestinal transit, which can reduce the absorption of oral digoxin tablets, especially slowly dissolving formulations. Serum digoxin levels may fall and reduce control of heart rate or heart failure symptoms.
What this interaction means in plain words
Digoxin and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Faster GI transit shortens the time available for digoxin tablet dissolution and absorption.
What to do
Monitor serum digoxin concentration and clinical response when metoclopramide is started or stopped. Adjust the digoxin dose if needed, or use a well-absorbed formulation such as liquid or capsule.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Metoclopramide?
MediHelp rates the interaction as moderate. Digoxin and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide speeds gastric emptying and intestinal transit, which can reduce the absorption of oral digoxin tablets, especially slowly dissolving formulations. Serum digoxin levels may fall and reduce control of heart rate or heart failure symptoms.
How serious is the interaction between Digoxin and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentration and clinical response when metoclopramide is started or stopped. Adjust the digoxin dose if needed, or use a well-absorbed formulation such as liquid or capsule.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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