Drug interactions
digoxin + sucralfate
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Sucralfate can adsorb digoxin in the GI tract, reducing its absorption and serum levels, potentially diminishing therapeutic effect.
Mechanism of action
Gastrointestinal adsorption by sucralfate (aluminum complex) decreases digoxin bioavailability.
Clinical management
Administer digoxin at least 2 hours before sucralfate; avoid simultaneous dosing. Monitor digoxin serum concentrations and clinical response when starting, stopping, or changing sucralfate.
Drug reference
References
- Carafate (sucralfate) Prescribing Information — FDA Label
- Digoxin–Sucralfate interaction monograph — Lexicomp
- Sucralfate: Drug interactions — UpToDate
Frequently asked questions
Can I take digoxin with sucralfate?
The interaction is rated: Moderate. Sucralfate can adsorb digoxin in the GI tract, reducing its absorption and serum levels, potentially diminishing therapeutic effect.
How serious is the interaction between digoxin and sucralfate?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between digoxin and sucralfate managed?
Administer digoxin at least 2 hours before sucralfate; avoid simultaneous dosing. Monitor digoxin serum concentrations and clinical response when starting, stopping, or changing sucralfate.
Why do digoxin and sucralfate interact?
Gastrointestinal adsorption by sucralfate (aluminum complex) decreases digoxin bioavailability.
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