Drug interactions
Digoxin + Tucatinib
Severity: Moderate
Digoxin and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib can increase digoxin exposure because digoxin is a sensitive P-glycoprotein substrate with a narrow therapeutic index. Elevated levels may cause bradycardia, arrhythmias, nausea and visual disturbance.
What this interaction means in plain words
Digoxin and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits intestinal and renal P-glycoprotein, increasing digoxin absorption and reducing its elimination.
What to do
Consider reducing the digoxin dose when starting tucatinib and monitor serum digoxin concentrations and ECG. Adjust the dose according to levels and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Digoxin and Tucatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Digoxin with Tucatinib?
MediHelp rates the interaction as moderate. Digoxin and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib can increase digoxin exposure because digoxin is a sensitive P-glycoprotein substrate with a narrow therapeutic index. Elevated levels may cause bradycardia, arrhythmias, nausea and visual disturbance.
How serious is the interaction between Digoxin and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the digoxin dose when starting tucatinib and monitor serum digoxin concentrations and ECG. Adjust the dose according to levels and clinical response.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
