Drug interactions
Disopyramide + Dolasetron
Severity: Major
Disopyramide and Dolasetron: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide is a class Ia antiarrhythmic that markedly prolongs the QT interval, and dolasetron slows conduction and prolongs repolarization too. Together they can precipitate torsades de pointes and conduction block.
What this interaction means in plain words
Disopyramide and Dolasetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Dolasetron belongs to Gastrointestinal Tract.
Why it happens
Additive effects on QT interval and cardiac conduction.
What to do
Avoid dolasetron in patients taking disopyramide and use a non-QT-prolonging antiemetic. If unavoidable, monitor ECG continuously or frequently and keep electrolytes normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Dolasetron?
MediHelp rates the interaction as major. Disopyramide and Dolasetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Disopyramide is a class Ia antiarrhythmic that markedly prolongs the QT interval, and dolasetron slows conduction and prolongs repolarization too. Together they can precipitate torsades de pointes and conduction block.
How serious is the interaction between Disopyramide and Dolasetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid dolasetron in patients taking disopyramide and use a non-QT-prolonging antiemetic. If unavoidable, monitor ECG continuously or frequently and keep electrolytes normal.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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