Drug interactions
Disopyramide + Nevirapine
Severity: Moderate
Disopyramide and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may lower disopyramide concentrations, risking loss of antiarrhythmic control. Disopyramide has a narrow therapeutic index, so changes in exposure can be relevant, although the interaction is predicted rather than well documented.
What this interaction means in plain words
Disopyramide and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Disopyramide belongs to Cardiovascular; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, increasing the N-dealkylation of disopyramide.
What to do
Monitor ECG and arrhythmia control, and consider serum disopyramide concentrations when nevirapine is started or stopped; adjust the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Nevirapine?
MediHelp rates the interaction as moderate. Disopyramide and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may lower disopyramide concentrations, risking loss of antiarrhythmic control. Disopyramide has a narrow therapeutic index, so changes in exposure can be relevant, although the interaction is predicted rather than well documented.
How serious is the interaction between Disopyramide and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and arrhythmia control, and consider serum disopyramide concentrations when nevirapine is started or stopped; adjust the dose as needed.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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