Drug interactions
Disopyramide + Palbociclib
Severity: Moderate
Disopyramide and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib is a weak time-dependent CYP3A4 inhibitor and may raise disopyramide exposure. Disopyramide has a narrow therapeutic index, and higher levels can increase anticholinergic effects, QT prolongation and arrhythmia risk.
What this interaction means in plain words
Disopyramide and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Disopyramide belongs to Cardiovascular; Palbociclib belongs to Oncology.
Why it happens
Palbociclib inhibits CYP3A4, reducing the metabolism of disopyramide.
What to do
Monitor ECG (QTc) and signs of disopyramide toxicity, and consider reducing the disopyramide dose or checking serum levels where available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palbociclib
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Palbociclib?
MediHelp rates the interaction as moderate. Disopyramide and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palbociclib is a weak time-dependent CYP3A4 inhibitor and may raise disopyramide exposure. Disopyramide has a narrow therapeutic index, and higher levels can increase anticholinergic effects, QT prolongation and arrhythmia risk.
How serious is the interaction between Disopyramide and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG (QTc) and signs of disopyramide toxicity, and consider reducing the disopyramide dose or checking serum levels where available.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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