Drug interactions
Disopyramide + Risperidone
Severity: Major
Disopyramide and Risperidone: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide is a class Ia antiarrhythmic with a clear risk of QT prolongation and torsades de pointes. Combined with risperidone, which also has QT effects, the arrhythmia risk increases.
What this interaction means in plain words
Disopyramide and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation through potassium channel blockade.
What to do
Avoid the combination if possible, and choose an alternative antipsychotic or antiarrhythmic. If unavoidable, monitor ECG and keep potassium and magnesium normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Okedi 100mg powder and solvent for prolonged-release suspension for injection pre-filled syringes - SmPC sections 4.3/4.5 (names the partner; "nterval Caution is advised when prescribing OKEDI with medicinal products known to prolong the QT interval, such as antiarrhythmics (e.g., quinidine, disopy… — electronic medicines compendium (UK SmPC)
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Risperidone?
MediHelp rates the interaction as major. Disopyramide and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Disopyramide is a class Ia antiarrhythmic with a clear risk of QT prolongation and torsades de pointes. Combined with risperidone, which also has QT effects, the arrhythmia risk increases.
How serious is the interaction between Disopyramide and Risperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, and choose an alternative antipsychotic or antiarrhythmic. If unavoidable, monitor ECG and keep potassium and magnesium normal.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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