Drug interactions
Disopyramide + Sevoflurane
Severity: Major
Disopyramide and Sevoflurane: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, and disopyramide is a class Ia antiarrhythmic with a known risk of torsades de pointes. Combining it with sevoflurane raises the chance of serious ventricular arrhythmia during anesthesia.
What this interaction means in plain words
Disopyramide and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive prolongation of ventricular repolarization through potassium channel effects.
What to do
Check baseline QTc and correct potassium and magnesium before anesthesia. Use continuous ECG monitoring and consider an alternative anesthetic approach in patients with a long QT interval.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sevoflurane
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Sevoflurane?
MediHelp rates the interaction as major. Disopyramide and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QT interval, and disopyramide is a class Ia antiarrhythmic with a known risk of torsades de pointes. Combining it with sevoflurane raises the chance of serious ventricular arrhythmia during anesthesia.
How serious is the interaction between Disopyramide and Sevoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline QTc and correct potassium and magnesium before anesthesia. Use continuous ECG monitoring and consider an alternative anesthetic approach in patients with a long QT interval.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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