Drug interactions
Dofetilide + Magnesium hydroxide
Severity: Minor
Dofetilide and Magnesium hydroxide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium hydroxide antacids are not known to alter dofetilide clearance in a meaningful way. The label names them as acceptable alternatives to cimetidine, which does raise dofetilide levels. No clinically significant interaction is expected.
What this interaction means in plain words
Dofetilide and Magnesium hydroxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dofetilide belongs to Cardiovascular; Magnesium hydroxide belongs to Gastrointestinal Tract.
Why it happens
No established pharmacokinetic or pharmacodynamic mechanism; it does not inhibit renal cation transport or CYP3A4 to a relevant extent.
What to do
No dose adjustment is needed. Keep checking electrolytes, especially magnesium and potassium, as part of routine dofetilide monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Other interactions of Magnesium hydroxide
Frequently asked questions
Can I take Dofetilide with Magnesium hydroxide?
MediHelp rates the interaction as minor. Dofetilide and Magnesium hydroxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Magnesium hydroxide antacids are not known to alter dofetilide clearance in a meaningful way. The label names them as acceptable alternatives to cimetidine, which does raise dofetilide levels. No clinically significant interaction is expected.
How serious is the interaction between Dofetilide and Magnesium hydroxide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Keep checking electrolytes, especially magnesium and potassium, as part of routine dofetilide monitoring.
What other medicines interact with Dofetilide?
MediHelp also lists interactions of Dofetilide with, for example, Amiodarone, Amisulpride, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Dofetilide page.
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