Drug interactions
Dofetilide + Omeprazole
Severity: Minor
Dofetilide and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole did not meaningfully change dofetilide pharmacokinetics in interaction studies and is named in the label as an acceptable acid suppressant. No clinically important interaction is expected.
What this interaction means in plain words
Dofetilide and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dofetilide belongs to Cardiovascular; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
No relevant interaction with renal cation secretion or dofetilide metabolism has been established.
What to do
No dose adjustment is needed. Continue routine QTc and renal function monitoring for dofetilide therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Dofetilide with Omeprazole?
MediHelp rates the interaction as minor. Dofetilide and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omeprazole did not meaningfully change dofetilide pharmacokinetics in interaction studies and is named in the label as an acceptable acid suppressant. No clinically important interaction is expected.
How serious is the interaction between Dofetilide and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Continue routine QTc and renal function monitoring for dofetilide therapy.
What other medicines interact with Dofetilide?
MediHelp also lists interactions of Dofetilide with, for example, Amiodarone, Amisulpride, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Dofetilide page.
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