Drug interactions
Dolasetron + Leuprolide
Severity: Moderate
Dolasetron and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with leuprolide can lengthen the QT interval, and dolasetron also prolongs cardiac conduction intervals. Using them together may increase the risk of torsades de pointes.
What this interaction means in plain words
Dolasetron and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Leuprolide belongs to Endocrine.
Why it happens
Additive QT prolongation; androgen deprivation alters cardiac repolarization.
What to do
Check baseline ECG and electrolytes, and monitor QTc in patients with cardiac risk factors. Consider an alternative antiemetic if QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Dolasetron with Leuprolide?
MediHelp rates the interaction as moderate. Dolasetron and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with leuprolide can lengthen the QT interval, and dolasetron also prolongs cardiac conduction intervals. Using them together may increase the risk of torsades de pointes.
How serious is the interaction between Dolasetron and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes, and monitor QTc in patients with cardiac risk factors. Consider an alternative antiemetic if QTc is prolonged.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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