Drug interactions
Dolasetron + Pentamidine
Severity: Major
Dolasetron and Pentamidine: major interaction.
Last updated Sources: CIMA AEMPS (Spain)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and giving them together raises the chance of torsades de pointes and other serious ventricular arrhythmias. Risk is greater with electrolyte disturbances, bradycardia or underlying heart disease.
What this interaction means in plain words
Dolasetron and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dolasetron belongs to Gastrointestinal Tract; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive delayed cardiac repolarization through blockade of cardiac potassium channels.
What to do
Use a non-QT-prolonging antiemetic such as a corticosteroid or an alternative if possible. If unavoidable, correct potassium and magnesium first and monitor the ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Dolasetron with Pentamidine?
MediHelp rates the interaction as major. Dolasetron and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and giving them together raises the chance of torsades de pointes and other serious ventricular arrhythmias. Risk is greater with electrolyte disturbances, bradycardia or underlying heart disease.
How serious is the interaction between Dolasetron and Pentamidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-QT-prolonging antiemetic such as a corticosteroid or an alternative if possible. If unavoidable, correct potassium and magnesium first and monitor the ECG.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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