Drug interactions
Dolasetron + Posaconazole
Severity: Major
Dolasetron and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole prolongs the QT interval and dolasetron has additive effects on cardiac conduction. The combination may increase the risk of torsades de pointes, particularly with electrolyte disturbances.
What this interaction means in plain words
Dolasetron and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dolasetron belongs to Gastrointestinal Tract; Posaconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation; CYP3A4 inhibition by posaconazole may also raise exposure to the dolasetron metabolite.
What to do
Avoid if possible by selecting an antiemetic without QT effect. If used, obtain ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Dolasetron with Posaconazole?
MediHelp rates the interaction as major. Dolasetron and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole prolongs the QT interval and dolasetron has additive effects on cardiac conduction. The combination may increase the risk of torsades de pointes, particularly with electrolyte disturbances.
How serious is the interaction between Dolasetron and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible by selecting an antiemetic without QT effect. If used, obtain ECG and correct potassium and magnesium.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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