Drug interactions
Dulaglutide + Empagliflozin
Severity: Minor
Dulaglutide and Empagliflozin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dulaglutide and empagliflozin are commonly combined for additive glycemic, weight and cardiovascular benefit. Hypoglycemia is rare unless insulin or a sulfonylurea is also used. Dehydration from vomiting or diarrhea can add to the diuretic effect of empagliflozin.
What this interaction means in plain words
Dulaglutide and Empagliflozin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dulaglutide belongs to Endocrine; Empagliflozin belongs to Endocrine.
Why it happens
Complementary mechanisms: incretin-mediated insulin secretion plus SGLT2-mediated urinary glucose excretion.
What to do
Monitor glucose and hydration, especially during gastrointestinal illness. Reduce any concurrent insulin or sulfonylurea dose at initiation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dulaglutide
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Dulaglutide with Empagliflozin?
MediHelp rates the interaction as minor. Dulaglutide and Empagliflozin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dulaglutide and empagliflozin are commonly combined for additive glycemic, weight and cardiovascular benefit. Hypoglycemia is rare unless insulin or a sulfonylurea is also used. Dehydration from vomiting or diarrhea can add to the diuretic effect of empagliflozin.
How serious is the interaction between Dulaglutide and Empagliflozin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and hydration, especially during gastrointestinal illness. Reduce any concurrent insulin or sulfonylurea dose at initiation.
What other medicines interact with Dulaglutide?
MediHelp also lists interactions of Dulaglutide with, for example, Insulin degludec-liraglutide, Insulin glargine-lixisenatide, Alogliptin-metformin. The full list is on the Dulaglutide page.
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