Drug interactions
Duloxetine + Glofitamab
Severity: Moderate
Duloxetine and Glofitamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab causes cytokine release syndrome, which can transiently suppress CYP enzyme activity. Duloxetine, cleared by CYP1A2 and CYP2D6, may therefore reach higher concentrations during and after CRS, increasing adverse effects.
What this interaction means in plain words
Duloxetine and Glofitamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Glofitamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP1A2 and CYP2D6 reduces duloxetine clearance.
What to do
Monitor for duloxetine adverse effects around the first doses and during any CRS. Adjust the duloxetine dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
Frequently asked questions
Can I take Duloxetine with Glofitamab?
MediHelp rates the interaction as moderate. Duloxetine and Glofitamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glofitamab causes cytokine release syndrome, which can transiently suppress CYP enzyme activity. Duloxetine, cleared by CYP1A2 and CYP2D6, may therefore reach higher concentrations during and after CRS, increasing adverse effects.
How serious is the interaction between Duloxetine and Glofitamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duloxetine adverse effects around the first doses and during any CRS. Adjust the duloxetine dose if toxicity occurs.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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