Drug interactions
Duloxetine + Lisdexamfetamine
Severity: Major
Duloxetine and Lisdexamfetamine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs increase central monoamine activity, and combining them can cause serotonin syndrome with agitation, tremor, hyperthermia and autonomic instability. Amphetamines can also raise blood pressure and heart rate in addition to duloxetine's effect.
What this interaction means in plain words
Duloxetine and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duloxetine belongs to Central Nervous System; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Additive serotonergic and noradrenergic effects from monoamine release (lisdexamfetamine) and reuptake inhibition (duloxetine).
What to do
Use the lowest effective doses and monitor for serotonin toxicity and blood pressure, especially at initiation and after dose increases. Stop both agents and treat supportively if serotonin syndrome develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Duloxetine with Lisdexamfetamine?
MediHelp rates the interaction as major. Duloxetine and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs increase central monoamine activity, and combining them can cause serotonin syndrome with agitation, tremor, hyperthermia and autonomic instability. Amphetamines can also raise blood pressure and heart rate in addition to duloxetine's effect.
How serious is the interaction between Duloxetine and Lisdexamfetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for serotonin toxicity and blood pressure, especially at initiation and after dose increases. Stop both agents and treat supportively if serotonin syndrome develops.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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