Drug interactions
Duloxetine + Teriflunomide
Severity: Minor
Duloxetine and Teriflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide is a weak CYP1A2 inducer and may lower exposure to CYP1A2 substrates such as duloxetine. The effect is likely modest but could reduce antidepressant or analgesic response.
What this interaction means in plain words
Duloxetine and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Duloxetine belongs to Central Nervous System; Teriflunomide belongs to Central Nervous System.
Why it happens
Teriflunomide weakly induces CYP1A2, increasing duloxetine clearance.
What to do
Monitor duloxetine efficacy and increase the dose if response is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Teriflunomide
Frequently asked questions
Can I take Duloxetine with Teriflunomide?
MediHelp rates the interaction as minor. Duloxetine and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide is a weak CYP1A2 inducer and may lower exposure to CYP1A2 substrates such as duloxetine. The effect is likely modest but could reduce antidepressant or analgesic response.
How serious is the interaction between Duloxetine and Teriflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor duloxetine efficacy and increase the dose if response is lost.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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