Drug interactions
Dutasteride + Fluconazole
Severity: Minor
Dutasteride and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP3A4, the main enzyme that clears dutasteride, so dutasteride exposure may rise modestly. Dutasteride has a wide safety margin and a very long half-life, so the clinical effect is usually small.
What this interaction means in plain words
Dutasteride and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dutasteride belongs to Genitourinary; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibition of CYP3A4-mediated metabolism of dutasteride.
What to do
No dose change is usually needed; watch for sexual adverse effects or breast tenderness if a long course of fluconazole is given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride
- Dutasteride + Levoketoconazole Moderate
- Dutasteride + Nefazodone Moderate
- Dutasteride + Rifampin Moderate
- Dutasteride + St john's wort Moderate
- Amobarbital + Dutasteride Minor
- Aprepitant + Dutasteride Minor
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Dutasteride with Fluconazole?
MediHelp rates the interaction as minor. Dutasteride and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole inhibits CYP3A4, the main enzyme that clears dutasteride, so dutasteride exposure may rise modestly. Dutasteride has a wide safety margin and a very long half-life, so the clinical effect is usually small.
How serious is the interaction between Dutasteride and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; watch for sexual adverse effects or breast tenderness if a long course of fluconazole is given.
What other medicines interact with Dutasteride?
MediHelp also lists interactions of Dutasteride with, for example, Levoketoconazole, Nefazodone, Rifampin. The full list is on the Dutasteride page.
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