Drug interactions
Elagolix + Estradiol
Severity: Minor
Elagolix and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak to moderate CYP3A4 inducer and may modestly lower estradiol levels. Elagolix also acts as a GnRH antagonist and is often combined with add-back estradiol, so any effect is generally planned for and manageable.
What this interaction means in plain words
Elagolix and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Estradiol belongs to Endocrine.
Why it happens
Weak to moderate CYP3A4 induction by elagolix increases estradiol metabolism.
What to do
Use estradiol add-back at the labeled dose and monitor for symptom control, adjusting if vasomotor symptoms or bone loss concerns persist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Estradiol?
MediHelp rates the interaction as minor. Elagolix and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak to moderate CYP3A4 inducer and may modestly lower estradiol levels. Elagolix also acts as a GnRH antagonist and is often combined with add-back estradiol, so any effect is generally planned for and manageable.
How serious is the interaction between Elagolix and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use estradiol add-back at the labeled dose and monitor for symptom control, adjusting if vasomotor symptoms or bone loss concerns persist.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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