Drug interactions
Elagolix + Everolimus
Severity: Moderate
Elagolix and Everolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix has opposing effects, inhibiting P-glycoprotein while weakly to moderately inducing CYP3A4, so the net effect on everolimus exposure is unpredictable. Concentrations could rise or fall.
What this interaction means in plain words
Elagolix and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Everolimus belongs to Oncology.
Why it happens
Elagolix inhibits P-glycoprotein and induces CYP3A4, with variable net effect on everolimus.
What to do
Monitor everolimus trough concentrations after starting or stopping elagolix and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Everolimus?
MediHelp rates the interaction as moderate. Elagolix and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix has opposing effects, inhibiting P-glycoprotein while weakly to moderately inducing CYP3A4, so the net effect on everolimus exposure is unpredictable. Concentrations could rise or fall.
How serious is the interaction between Elagolix and Everolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough concentrations after starting or stopping elagolix and adjust the dose accordingly.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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