Drug interactions
Elagolix + Loratadine
Severity: Minor
Elagolix and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix can inhibit P-glycoprotein and may modestly increase exposure to loratadine. Given loratadine's wide therapeutic index, clinical consequences are expected to be small.
What this interaction means in plain words
Elagolix and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Loratadine belongs to Respiratory.
Why it happens
Elagolix inhibits intestinal P-glycoprotein, reducing efflux of loratadine.
What to do
No dose adjustment is generally required; monitor for increased drowsiness or headache.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Loratadine?
MediHelp rates the interaction as minor. Elagolix and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix can inhibit P-glycoprotein and may modestly increase exposure to loratadine. Given loratadine's wide therapeutic index, clinical consequences are expected to be small.
How serious is the interaction between Elagolix and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required; monitor for increased drowsiness or headache.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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