Drug interactions
Elagolix + Modafinil
Severity: Minor
Elagolix and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix weakly inhibits CYP2C19 and weakly to moderately induces CYP3A4, so modafinil exposure could be changed in either direction. The net effect is likely small.
What this interaction means in plain words
Elagolix and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Modafinil belongs to Central Nervous System.
Why it happens
Elagolix inhibition of CYP2C19 and induction of CYP3A4 affecting modafinil metabolism.
What to do
Monitor modafinil response and tolerability. Adjust the dose only if clinical effect changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Modafinil?
MediHelp rates the interaction as minor. Elagolix and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix weakly inhibits CYP2C19 and weakly to moderately induces CYP3A4, so modafinil exposure could be changed in either direction. The net effect is likely small.
How serious is the interaction between Elagolix and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor modafinil response and tolerability. Adjust the dose only if clinical effect changes.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
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