Drug interactions
Elagolix + Ondansetron
Severity: Minor
Elagolix and Ondansetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak to moderate CYP3A inducer and a P-gp inhibitor, with opposing possible effects on ondansetron exposure. The net effect is uncertain and likely small because ondansetron has several clearance pathways.
What this interaction means in plain words
Elagolix and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
CYP3A induction may lower ondansetron levels while P-gp inhibition may raise them.
What to do
No dose adjustment is routinely required. Monitor antiemetic response and tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Ondansetron?
MediHelp rates the interaction as minor. Elagolix and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak to moderate CYP3A inducer and a P-gp inhibitor, with opposing possible effects on ondansetron exposure. The net effect is uncertain and likely small because ondansetron has several clearance pathways.
How serious is the interaction between Elagolix and Ondansetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely required. Monitor antiemetic response and tolerability.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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