Drug interactions
Elagolix + Palbociclib
Severity: Moderate
Elagolix and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer and may lower palbociclib concentrations. This could reduce antitumor efficacy, although the clinical impact has not been well characterized.
What this interaction means in plain words
Elagolix and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Palbociclib belongs to Oncology.
Why it happens
Elagolix induces CYP3A4, increasing the metabolism of palbociclib.
What to do
Avoid the combination where possible, as elagolix is rarely needed in patients on palbociclib; otherwise monitor for reduced tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palbociclib
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Palbociclib?
MediHelp rates the interaction as moderate. Elagolix and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a weak-to-moderate CYP3A4 inducer and may lower palbociclib concentrations. This could reduce antitumor efficacy, although the clinical impact has not been well characterized.
How serious is the interaction between Elagolix and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, as elagolix is rarely needed in patients on palbociclib; otherwise monitor for reduced tumor response.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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