Drug interactions
Elagolix + Ranolazine
Severity: Moderate
Elagolix and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A inducer and may lower ranolazine plasma concentrations, reducing antianginal effect. It may also inhibit intestinal P-gp, which could raise ranolazine exposure, so the net effect is uncertain.
What this interaction means in plain words
Elagolix and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Ranolazine belongs to Cardiovascular.
Why it happens
Elagolix induces CYP3A4 (lowering ranolazine exposure) and may inhibit P-glycoprotein (raising it), giving an unpredictable net effect.
What to do
Monitor angina control and ranolazine tolerability when starting or stopping elagolix. Adjust the ranolazine dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Ranolazine?
MediHelp rates the interaction as moderate. Elagolix and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a weak-to-moderate CYP3A inducer and may lower ranolazine plasma concentrations, reducing antianginal effect. It may also inhibit intestinal P-gp, which could raise ranolazine exposure, so the net effect is uncertain.
How serious is the interaction between Elagolix and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor angina control and ranolazine tolerability when starting or stopping elagolix. Adjust the ranolazine dose according to response.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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