Drug interactions
Elagolix + Risperidone
Severity: Minor
Elagolix and Risperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak inhibitor of intestinal P-glycoprotein and may modestly raise exposure to risperidone, a P-gp substrate. The clinical effect is likely small and shows up as increased risperidone adverse effects.
What this interaction means in plain words
Elagolix and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Risperidone belongs to Central Nervous System.
Why it happens
Inhibition of P-glycoprotein efflux, which increases risperidone absorption and reduces its clearance.
What to do
No routine dose change is needed; watch for sedation, orthostasis or extrapyramidal symptoms when starting elagolix.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Risperidone?
MediHelp rates the interaction as minor. Elagolix and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak inhibitor of intestinal P-glycoprotein and may modestly raise exposure to risperidone, a P-gp substrate. The clinical effect is likely small and shows up as increased risperidone adverse effects.
How serious is the interaction between Elagolix and Risperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for sedation, orthostasis or extrapyramidal symptoms when starting elagolix.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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