Drug interactions
Elagolix + Temsirolimus
Severity: Moderate
Elagolix and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a P-glycoprotein inhibitor and a weak-to-moderate CYP3A4 inducer, so effects on temsirolimus exposure may go in either direction. The net clinical effect is unpredictable.
What this interaction means in plain words
Elagolix and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Temsirolimus belongs to Oncology.
Why it happens
Combined P-glycoprotein inhibition and CYP3A4 induction by elagolix.
What to do
Monitor for temsirolimus toxicity and for reduced efficacy. Adjust dosing according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Temsirolimus?
MediHelp rates the interaction as moderate. Elagolix and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a P-glycoprotein inhibitor and a weak-to-moderate CYP3A4 inducer, so effects on temsirolimus exposure may go in either direction. The net clinical effect is unpredictable.
How serious is the interaction between Elagolix and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for temsirolimus toxicity and for reduced efficacy. Adjust dosing according to clinical response.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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