Drug interactions
Elagolix + Trazodone
Severity: Minor
Elagolix and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak to moderate CYP3A4 inducer and may lower trazodone concentrations. This could reduce trazodone's therapeutic effect.
What this interaction means in plain words
Elagolix and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Elagolix induces CYP3A4, increasing trazodone metabolism.
What to do
Monitor clinical response to trazodone and increase the dose if effect is reduced. Reassess after elagolix is stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Trazodone?
MediHelp rates the interaction as minor. Elagolix and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak to moderate CYP3A4 inducer and may lower trazodone concentrations. This could reduce trazodone's therapeutic effect.
How serious is the interaction between Elagolix and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to trazodone and increase the dose if effect is reduced. Reassess after elagolix is stopped.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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