Drug interactions
Elagolix + Trimipramine
Severity: Minor
Elagolix and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix has mixed enzyme effects, weakly inhibiting CYP2C19 and weakly to moderately inducing CYP3A4. Trimipramine exposure could therefore move in either direction, with the net effect uncertain.
What this interaction means in plain words
Elagolix and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Trimipramine belongs to Central Nervous System.
Why it happens
Weak CYP2C19 inhibition combined with CYP3A4 induction altering trimipramine metabolism.
What to do
Monitor clinical response and adverse effects of trimipramine after elagolix is started or stopped. Adjust the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Trimipramine?
MediHelp rates the interaction as minor. Elagolix and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix has mixed enzyme effects, weakly inhibiting CYP2C19 and weakly to moderately inducing CYP3A4. Trimipramine exposure could therefore move in either direction, with the net effect uncertain.
How serious is the interaction between Elagolix and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and adverse effects of trimipramine after elagolix is started or stopped. Adjust the dose if needed.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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