Drug interactions
Elagolix + Zonisamide
Severity: Minor
Elagolix and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer and may speed up the metabolism of zonisamide, which is partly cleared by CYP3A4. Zonisamide exposure could fall, with a risk of reduced seizure control in patients who depend on a stable concentration.
What this interaction means in plain words
Elagolix and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Zonisamide belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by elagolix increases the hepatic and intestinal metabolism of zonisamide.
What to do
Watch for loss of seizure control after elagolix is started and consider raising the zonisamide dose or checking serum levels if control worsens. Reassess the dose when elagolix is stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Zonisamide?
MediHelp rates the interaction as minor. Elagolix and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak-to-moderate CYP3A4 inducer and may speed up the metabolism of zonisamide, which is partly cleared by CYP3A4. Zonisamide exposure could fall, with a risk of reduced seizure control in patients who depend on a stable concentration.
How serious is the interaction between Elagolix and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for loss of seizure control after elagolix is started and consider raising the zonisamide dose or checking serum levels if control worsens. Reassess the dose when elagolix is stopped.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Zuranolone, Acetazolamide, Amisulpride. The full list is on the Zonisamide page.
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