Drug interactions
Eletriptan + Lisdexamfetamine
Severity: Moderate
Eletriptan and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamine increases serotonin and norepinephrine activity, and eletriptan is a serotonin receptor agonist. Taken together they may produce additive serotonergic effects, and blood pressure may rise.
What this interaction means in plain words
Eletriptan and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Additive serotonergic and vasopressor effects.
What to do
Counsel the patient to report agitation, tremor, sweating or fever. Monitor blood pressure and stop one drug if serotonin syndrome occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Eletriptan and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamine increases serotonin and norepinephrine activity, and eletriptan is a serotonin receptor agonist. Taken together they may produce additive serotonergic effects, and blood pressure may rise.
How serious is the interaction between Eletriptan and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report agitation, tremor, sweating or fever. Monitor blood pressure and stop one drug if serotonin syndrome occurs.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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