Drug interactions
Eletriptan + Posaconazole
Severity: Major
Eletriptan and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eletriptan is extensively metabolized by CYP3A4, and strong inhibitors markedly increase its exposure, raising the risk of vasoconstrictive and cardiovascular adverse effects. Eletriptan labeling advises against use with strong CYP3A4 inhibitors.
What this interaction means in plain words
Eletriptan and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eletriptan belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4, reducing first-pass and systemic clearance of eletriptan.
What to do
Avoid eletriptan during and for at least 72 hours after posaconazole therapy; choose a triptan not dependent on CYP3A4, such as sumatriptan or rizatriptan.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Posaconazole?
MediHelp rates the interaction as major. Eletriptan and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eletriptan is extensively metabolized by CYP3A4, and strong inhibitors markedly increase its exposure, raising the risk of vasoconstrictive and cardiovascular adverse effects. Eletriptan labeling advises against use with strong CYP3A4 inhibitors.
How serious is the interaction between Eletriptan and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid eletriptan during and for at least 72 hours after posaconazole therapy; choose a triptan not dependent on CYP3A4, such as sumatriptan or rizatriptan.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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