Drug interactions
Eletriptan + Tepotinib
Severity: Moderate
Eletriptan and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein, and eletriptan is a P-gp substrate. Eletriptan exposure may be increased, with possible higher blood pressure and other triptan effects. The magnitude is not well characterized for eletriptan.
What this interaction means in plain words
Eletriptan and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Tepotinib belongs to Oncology.
Why it happens
P-gp inhibition by tepotinib may increase eletriptan absorption and reduce efflux.
What to do
Monitor blood pressure and triptan adverse effects. Consider an alternative triptan if effects are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Eletriptan with Tepotinib?
MediHelp rates the interaction as moderate. Eletriptan and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-glycoprotein, and eletriptan is a P-gp substrate. Eletriptan exposure may be increased, with possible higher blood pressure and other triptan effects. The magnitude is not well characterized for eletriptan.
How serious is the interaction between Eletriptan and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and triptan adverse effects. Consider an alternative triptan if effects are troublesome.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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