Drug interactions
Eliglustat + Mitomycin
Severity: Minor
Eliglustat and Mitomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein and may raise exposure to substrates such as mitomycin. This could increase mitomycin toxicity, notably myelosuppression.
What this interaction means in plain words
Eliglustat and Mitomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eliglustat belongs to Miscellaneous; Mitomycin belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux by eliglustat may increase mitomycin exposure.
What to do
Monitor blood counts and signs of mitomycin toxicity during co-administration. Reduce the mitomycin dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Mitomycin?
MediHelp rates the interaction as minor. Eliglustat and Mitomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eliglustat inhibits P-glycoprotein and may raise exposure to substrates such as mitomycin. This could increase mitomycin toxicity, notably myelosuppression.
How serious is the interaction between Eliglustat and Mitomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of mitomycin toxicity during co-administration. Reduce the mitomycin dose if adverse effects occur.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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