Drug interactions
Empagliflozin + Enalapril-hydrochlorothiazide
Severity: Moderate
Empagliflozin and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin has a diuretic effect, and with hydrochlorothiazide and enalapril it increases the risk of volume depletion, hypotension and acute kidney injury. Risk is higher in elderly or volume-depleted patients.
What this interaction means in plain words
Empagliflozin and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin belongs to Endocrine; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive osmotic diuresis and natriuresis with thiazide diuretic activity and RAAS inhibition.
What to do
Assess volume status before starting and monitor blood pressure and renal function. Consider reducing the diuretic dose if volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Empagliflozin with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Empagliflozin and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin has a diuretic effect, and with hydrochlorothiazide and enalapril it increases the risk of volume depletion, hypotension and acute kidney injury. Risk is higher in elderly or volume-depleted patients.
How serious is the interaction between Empagliflozin and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status before starting and monitor blood pressure and renal function. Consider reducing the diuretic dose if volume depletion develops.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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