Drug interactions
Empagliflozin + Hydrochlorothiazide-losartan
Severity: Moderate
Empagliflozin and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin has an osmotic diuretic effect and adds to the diuresis of hydrochlorothiazide. The combination can cause volume depletion, hypotension and acute kidney injury, particularly in elderly patients or those with reduced renal function.
What this interaction means in plain words
Empagliflozin and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin belongs to Endocrine; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Additive diuretic and natriuretic effects leading to intravascular volume depletion.
What to do
Assess volume status and renal function before and after starting empagliflozin. Consider lowering the diuretic dose in patients at risk and advise about hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Empagliflozin with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Empagliflozin and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin has an osmotic diuretic effect and adds to the diuresis of hydrochlorothiazide. The combination can cause volume depletion, hypotension and acute kidney injury, particularly in elderly patients or those with reduced renal function.
How serious is the interaction between Empagliflozin and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and renal function before and after starting empagliflozin. Consider lowering the diuretic dose in patients at risk and advise about hydration.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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